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Increasing your healthspan (i.e. making 100 years old the new 60) will depend to a large degree on artificial intelligence. And, as we saw in last week’s blog, healthcare AI systems are extremely data-hungry. Fortunately, a slew of new sensors and data acquisition methods — including over 122 million wearables shipped in 2018 — are bursting onto the scene to meet the massive demand for medical data. From ubiquitous biosensors, to the mobile healthcare revolution, to the transformative power of the Health Nucleus, converging exponential technologies are fundamentally transforming our approach to healthcare. In Part 4 of this blog series on Longevity & Vitality, I expand on how we’re acquiring the data to fuel today's AI healthcare revolution. In this blog, I’ll explore: How the Health Nucleus is transforming “sick care” to healthcare Sensors, wearables and nanobots The advent of mobile health Let’s dive in. Health Nucleus: Transforming ‘Sick Care’ to Healthcare Much of today’s healthcare system is actually sick care. Most of us assume that we’re perfectly healthy, with nothing going on inside our bodies, until the day we travel to the hospital writhing in pain only to discover a serious or life-threatening condition. Chances are that your ailment didn’t materialize that morning; rather, it’s been growing or developing for some time. You simply weren’t aware of it. At that point, once you’re diagnosed as “sick,” our medical system engages to take care of you. What if, instead of this retrospective and reactive approach, you were constantly monitored, so that you could know the moment anything was out of whack? Better yet, what if you more closely monitored those aspects of your body that your gene sequence predicted might cause you difficulty? Think: your heart, your kidney, your breasts. Such a system becomes personalized, predictive and possibly preventative. This is the mission of the Health Nucleus platform built by Human Longevity, Inc. (HLI). While not continuous — that will come later, with the next generation of wearable and implantable sensors — the Health Nucleus was designed to ‘digitize’ you once per year to help you determine whether anything is going on inside your body that requires immediate attention. The Health Nucleus visit provides you with the following tests during a half-day visit: Whole genome sequencing (30x coverage) Whole body (non-contrast) MRI Brain magnetic resonance imaging/angiography (MRI/MRA) CT (computed tomography) of the heart and lungs Coronary artery calcium scoring Electrocardiogram Echocardiogram Continuous cardiac monitoring Clinical laboratory tests and metabolomics In late 2018, HLI published the results of the first 1,190 clients through the Health Nucleus. The results were eye-opening — especially since these patients were all financially well-off, and already had access to the best doctors. Following are the physiological and genomic findings in these clients who self-selected to undergo evaluation at HLI’s Health Nucleus. Physiological Findings [TG] 2 percent had previously unknown tumors detected by MRI 2.5 percent had previously undetected aneurysms detected by MRI 8 percent had cardiac arrhythmia found on cardiac rhythm monitoring, not previously known 9 percent had moderate-severe coronary artery disease risk, not previously known 16 percent discovered previously unknown cardiac structure/function abnormalities 30 percent had elevated liver fat, not previously known Genomic Findings [TG] 24 percent of clients uncovered a rare (unknown) genetic mutation found on WGS 63 percent of clients had a rare genetic mutation with a corresponding phenotypic finding In summary, HLI’s published results found that 14.4 percent of clients had significant findings that are actionable, requiring immediate or near-term follow-up and intervention. Long-term value findings were found in 40 percent of the clients we screened. Long-term clinical findings include discove